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Common considerations include drug exposure, at least one lupus-like symptom, no previous SLE history, and symptom resolution after discontinuation ( Worldwide, 19 cases of methimazole-induced lupus have been documented, including the present case, with only six pediatric cases reported till date (Table 3

Literature data indicate that more than 20 different thiamine pyrophosphate-dependent enzymes are known, most of which are found in prokaryotes: transketolase [16], phosphonopyruvate decarboxylase [17], pyruvate dehydrogenase complex [18], branched-chain amino acid enzyme [19], phosphoketolase [20], benzoylformate decarboxylase [21], pyruvate decarboxylase [22], 2-oxoglutarate dehydrogenase complex [23], sulfopyruvate decarboxylase [24], pyruvate ferredoxinoxidoreductase [25], phenylpyruvate decarboxylase [26], 2-hydroxyphytanoyl-CoA lyase [27], acetohydroxyacid synthases [28], glyoxylate carboligase [29], and others

HIF-1alpha inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein

12 (5), R201